Enhanced Ca 2+ -Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation.

Jordi Heijman Xiao-Bo Zhou Stefano Morotti Cristina E Molina Issam H Abu-TahaMarcel TekookThomas JespersenYiqiao ZhangShokoufeh DobrevAndreas BrodehlJan GummertMatthias KarckMarkus KamlerAli El-ArmoucheArnela SaljicEleonora GrandiStanley Nattel Dobromir Dobrev

Published in: Circulation research (2023)

, which promote reentry-stabilizing action potential duration shortening, suggest an important role for SK-channels in AF auto-promotion and provide a rationale for pursuing the antiarrhythmic effects of SK-channel inhibition in humans.

Keyphrases

atrial fibrillation
catheter ablation
endothelial cells
left atrial
oral anticoagulants
left atrial appendage
heart failure
direct oral anticoagulants
induced pluripotent stem cells
climate change