Hypofractionated FLASH-RT as an Effective Treatment against Glioblastoma that Reduces Neurocognitive Side Effects in Mice.

Pierre Montay-Gruel Munjal M AcharyaPatrik Gonçalves JorgeBenoît PetitIoannis G PetridisPhilippe FuchsRon LeavittKristoffer PeterssonMaude GondréJonathan OllivierRaphaël Moeckli François O BochudClaude BailatJean BourhisJean-François GermondCharles L LimoliMarie-Catherine Vozenin

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

The present results show that FLASH-RT delivered with hypofractionated regimens is able to spare the normal brain from radiation-induced toxicities without compromising tumor cure. This exciting capability provides an initial framework for future clinical applications of FLASH-RT.See related commentary by Huang and Mendonca, p. 662.

Keyphrases

radiation induced
radiation therapy
white matter
bipolar disorder
brain metastases
small cell lung cancer
high fat diet induced
type diabetes
current status
adipose tissue
brain injury