Heterogeneity in Response to Treatment of Adolescents with Severe Obesity: The Need for Precision Obesity Medicine.

Justin R RyderAlexander M KaizerTodd M JenkinsAaron S KellyThomas H IngeGabriel Q Shaibi

Published in: Obesity (Silver Spring, Md.) (2020)

Adolescents with severe obesity demonstrated a high degree of heterogeneity in terms of BMI reduction and cardiometabolic risk factor response across treatment modalities. Reporting individual response data in trials and identifying factors driving variability in response will be vital for advancing precision medicine approaches to address obesity.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
weight gain
high fat diet induced
type diabetes
young adults
physical activity
risk factors
single cell
early onset
skeletal muscle
combination therapy
electronic health record
big data
artificial intelligence
drug induced