Malondialdehyde-Acetaldehyde Adducts and Antibody Responses in Rheumatoid Arthritis-Associated Interstitial Lung Disease.

Bryant R EnglandMichael J DuryeePunyasha RoulTina D MahajanNamrata SinghJill A PooleDana P AschermanLiron CaplanM Kristen DemoruelleKevin D DeaneLynell W KlassenGeoffrey M ThieleTed R Mikuls

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)

Serum IgA and IgM anti-MAA antibody is associated with ILD among RA patients. MAA is highly expressed in RA-ILD lung tissue, where it colocalizes with other RA autoantigens, autoreactive B cells, and extracellular matrix proteins, highlighting its potential role in the pathogenesis of RA-ILD.

Keyphrases

interstitial lung disease
rheumatoid arthritis
systemic sclerosis
extracellular matrix
disease activity
idiopathic pulmonary fibrosis
end stage renal disease
ankylosing spondylitis
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
patient reported outcomes