Y chromosome AZFc microdeletion may have negative effect on embryo euploidy: a retrospective cohort study.

Wei JiangQijun XieXin LiYe YangTing LuanDanyu NiYuting ChenXinyu WangChun ZhaoXiufeng Ling

Published in: BMC medical genomics (2023)

Our study underscored the association between Y chromosome AZFc microdeletion and an elevated risk of embryo aneuploidy. Before the conventional intracytoplasmic sperm injection (ICSI) treatment, couples with Y chromosome AZFc microdeletion should be apprised of the heightened susceptibility to embryo aneuploidy. Preimplantation genetic testing for aneuploidy (PGT-A) should be introduced for selection.

Keyphrases

pregnancy outcomes
copy number
pregnant women
gene expression
dna methylation