Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients.
Barbara BojkoTijana VasiljevicEzel BoyaciAnna RoszkowskaNatalia KraevaCarlos A Ibarra MorenoAnnabel KoivuMarcin WąsowiczAmy HannaSusan HamiltonSheila RiaziJanusz PawliszynPublished in: Canadian journal of anaesthesia = Journal canadien d'anesthesie (2021)
This metabolomics study indicates a shift from utilization of carbohydrates towards lipids for energy production in MH-susceptible individuals. This shift may result in inefficiency of beta-oxidation, and increased muscle protein turnover, oxidative stress, and/or lysophosphatidylcholine levels.
Keyphrases
- skeletal muscle
- mass spectrometry
- oxidative stress
- end stage renal disease
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- type diabetes
- dna damage
- liquid chromatography
- metabolic syndrome
- ischemia reperfusion injury
- binding protein
- nitric oxide
- diabetic rats
- small molecule
- simultaneous determination
- heat stress