Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy.

Neda Rajamand EkbergSofie EliassonYoung Wen LiXiaowei ZhengKaterina ChatzidionysiouHenrik FalhammarHarvest F GuSergiu-Bogdan Catrina

Published in: Journal of diabetes research (2019)

The HIF-1A genetic polymorphism has a protective effect on the development of severe DR. Moreover, the relative resistance of the HIF-1A Pro582Ser polymorphism to the repressive effect of hyperglycemia is due to the transactivation activity rather than the protein stability of HIF-1α.

Keyphrases

diabetic retinopathy
endothelial cells
early onset
optical coherence tomography
anti inflammatory
gene expression
genome wide
drug induced
copy number
oxidative stress
protein protein