ADAMTS-1 in abdominal aortic aneurysm.

Emina VorkapicMaggie FolkessonKerstin MagnellMohammad Bohlooly-YToste LänneDick Wågsäter

Published in: PloS one (2017)

Several of the ADAMTS members, and especially ADAMTS-1, are down regulated at mRNA level in AAA, due to unknown mechanisms, at the same time ADAMTS-1 protein is induced. The cleavage of its substrates, don't seem to be crucial for the pathogenesis of AAA but rather more important in the development of thoracic aortic aneurysm and atherosclerosis as shown in previous studies.

Keyphrases

abdominal aortic aneurysm
aortic aneurysm
cardiovascular disease
spinal cord
binding protein
transcription factor
type diabetes
oxidative stress
amino acid
small molecule
protein protein