mTORC1 inhibition uncouples lipolysis and thermogenesis in white adipose tissue to contribute to alcoholic liver disease.

Qing Song Yingli Chen Qinchao Ding Alexandra GriffithsLifeng LiuJooman Park Chong Wee Liew Natalia Nieto Songtao Li Xiaobing Dou Yuwei Jiang

Published in: Hepatology communications (2023)

Chronic alcohol consumption induces an "uncoupling status" between lipolysis and browning/thermogenesis in WAT by inhibiting mTORC1 activation. Diminished WAT browning/thermogenesis, concomitant with enhanced lipolysis, contributes to ALD pathogenesis.

Keyphrases

adipose tissue
alcohol consumption
insulin resistance
high fat diet
high fat diet induced
signaling pathway
liver injury
drug induced
type diabetes
nitric oxide
nitric oxide synthase