Stereotaxic-assisted gene therapy in Alzheimer's and Parkinson's diseases: therapeutic potentials and clinical frontiers.
Samar O El GanainyTony CijsouwMennatallah A AliSusanne SchochAmira Sayed HanafyPublished in: Expert review of neurotherapeutics (2022)
Robotic stereotaxis combined with intraoperative imaging has revolutionized brain surgeries. While gene therapies are bringing huge innovations to the medical field and new hope to AD and PD patients and medical professionals, the efficient and targeted delivery of such therapies is a bottleneck. We propose that careful application of stereotaxic delivery of gene therapies can improve PD and AD management. [Figure: see text].
Keyphrases
- gene therapy
- end stage renal disease
- healthcare
- genome wide
- newly diagnosed
- copy number
- chronic kidney disease
- ejection fraction
- high resolution
- prognostic factors
- peritoneal dialysis
- patients undergoing
- white matter
- genome wide identification
- cognitive decline
- minimally invasive
- smoking cessation
- mass spectrometry
- brain injury
- fluorescence imaging