Two X-linked agammaglobulinemia patients develop pneumonia as COVID-19 manifestation but recover.
Annarosa SoresinaDaniele MorattoMarco ChiariniCiro PaolilloGiulia BaresiEmanuele FocàMichela BezziBarbara BaronioMauro GiacomelliRaffaele BadolatoPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2020)
Our report suggests that XLA patients might present with high risk to develop pneumonia after SARS-CoV-2 infection, but can recover from infection, suggesting that B-cell response might be important, but is not strictly required to overcome the disease. However, there is a need for larger observational studies to extend these conclusions to other patients with similar genetic immune defects.