Sildenafil prevents right ventricular hypertrophy and improves heart rate variability in rats with pulmonary hypertension secondary to experimental diabetes.
Miguel Angel Garcia-GonzalezVeronica Vallejo-RuizFausto Atonal-FloresJorge Flores-HernandezOswaldo Torres-RamírezAlfonso Diaz-FonsecaeFrancisco Perez VizcainoJose Gustavo Lopez-LopezPublished in: Clinical and experimental hypertension (New York, N.Y. : 1993) (2022)
Our results indicate for the first time that SILD treatment prevents pulmonary arterial endothelial dysfunction, pulmonary hypertension, right ventricular hypertrophy and improves heart rate variability in type 1 diabetic rats.