Glymphatic function assessment with diffusion tensor imaging along the perivascular space in patients with major depressive disorder and its relation to cerebral white-matter alteration.
Chun YangShiyun TianWei DuMeichen LiuRui HuBingbing GaoTao PanQingwei SongTieli LiuWeiwei WangHuimin ZhangYanwei MiaoPublished in: Quantitative imaging in medicine and surgery (2024)
Our results indicated a decrease in DTI-ALPS index score in patients with MDD. DTI-ALPS score was associated with depression, anxiety, declined cognitive ability, and white-matter microstructural abnormalities and may thus be a promising biomarker for the partial evaluation of glymphatic system function in patients with MDD.