Efficacy and tolerability of pharmacological interventions on metabolic disturbance induced by atypical antipsychotics in adults: A systematic review and network meta-analysis.

Yewei WangDandan WangJie ChengXinyu FangYan ChenLingfang YuJuanjuan RenYuan TianChen Zhang

Published in: Journal of psychopharmacology (Oxford, England) (2021)

Considering both efficacy and tolerability, evidence from this NMA indicates zonisamide, metformin, GLP-1RAs, and nizatidine in adults should be the first-line treatment for alleviating AAPs-induced weight gain or elevated BMI.

Keyphrases

weight gain
body mass index
birth weight
open label
weight loss
physical activity
high glucose
double blind
clinical trial
placebo controlled
endothelial cells
stress induced
preterm birth