Review article: Pathogenesis of MASLD and MASH - role of insulin resistance and lipotoxicity.

Published in: Alimentary pharmacology & therapeutics (2024)

Targeting tissue-specific insulin resistance and hyperinsulinaemia while decreasing FFA load (lipotoxicity) through dietary and lifestyle changes remain the best upstream interventions.

Keyphrases

insulin resistance
metabolic syndrome
adipose tissue
high fat diet
physical activity
polycystic ovary syndrome
skeletal muscle
type diabetes
high fat diet induced
cardiovascular disease
weight loss
cancer therapy
glycemic control
drug delivery