Thoracic bilateral sympathectomy attenuates oxidative stress and prevents ventricular remodelling in experimental pulmonary hypertension.
Raphael Dos Santos Coutinho E SilvaLucas Moritz WiggenhauserRafael SimasFernando Luiz ZanoniGeisla MedeirosFernanda Beatriz da SilvaDaniel Cury OgataAna Cristina Breithaupt-FaloppaGuido KrenningLuiz Felipe Pinho MoreiraPublished in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2022)
We showed that thoracic BS may be an important treatment option for PAH patients. Blockade of the sympathetic pathway can prevent pulmonary remodelling and protect the RV from oxidative stress, myocardial remodelling and function decay.
Keyphrases
- oxidative stress
- pulmonary hypertension
- spinal cord
- end stage renal disease
- left ventricular
- ejection fraction
- mycobacterium tuberculosis
- dna damage
- newly diagnosed
- heart failure
- pulmonary artery
- prognostic factors
- induced apoptosis
- pulmonary arterial hypertension
- patient reported outcomes
- mouse model
- endoplasmic reticulum stress
- patient reported
- atrial fibrillation
- combination therapy