Circulating Monocyte and Lymphocyte Populations in Healthy First-Degree Relatives of Type 2 Diabetic Patients at Fasting and during Short-Term Hyperinsulinemia.
Michaela ŠiklováEva KrauzováBarbora SvobodováJana KračmerováMarek ŠtěpánMichal KocVladimír ŠtichLenka RossmeislováPublished in: Mediators of inflammation (2019)
The alterations of the CD4/CD8 lymphocyte ratio, relative content of TH17 cells, and intermediate monocytes in FDR are features of genetic predisposition to T2DM and may play a role in pathogenesis of T2DM. Short-term hyperinsulinemia affected mostly the immune cell populations deregulated in FDR subjects, which suggests important interplay between immune system homeostasis and insulin levels.
Keyphrases
- peripheral blood
- glycemic control
- induced apoptosis
- dendritic cells
- type diabetes
- blood glucose
- cell cycle arrest
- genetic diversity
- insulin resistance
- endothelial cells
- endoplasmic reticulum stress
- signaling pathway
- gene expression
- blood pressure
- oxidative stress
- immune response
- metabolic syndrome
- dna methylation
- skeletal muscle