Levodopa Causes Striatal Cholinergic Interneuron Burst-Pause Activity in Parkinsonian Mice.
Rodrigo Manuel PazCecilia TubertAgostina Monica StahlYimy AmarilloLorena RelaMario Gustavo MurerPublished in: Movement disorders : official journal of the Movement Disorder Society (2021)
Our data unravel a mechanism causing aberrant cholinergic interneuron burst-pause activity in parkinsonian mice treated with levodopa. Targeting D5-cAMP signaling and the regulation of Kir2 and leak channels may alleviate parkinsonism and dyskinesia by restoring normal cholinergic interneuron function. © 2021 International Parkinson and Movement Disorder Society.