Levodopa Causes Striatal Cholinergic Interneuron Burst-Pause Activity in Parkinsonian Mice.

Rodrigo Manuel PazCecilia TubertAgostina Monica StahlYimy AmarilloLorena RelaMario Gustavo Murer

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

Our data unravel a mechanism causing aberrant cholinergic interneuron burst-pause activity in parkinsonian mice treated with levodopa. Targeting D5-cAMP signaling and the regulation of Kir2 and leak channels may alleviate parkinsonism and dyskinesia by restoring normal cholinergic interneuron function. © 2021 International Parkinson and Movement Disorder Society.

Keyphrases

parkinson disease
deep brain stimulation
high fat diet induced
high frequency
cancer therapy
insulin resistance
wild type
binding protein
type diabetes
protein kinase