Over Activation of IL-6/STAT3 Signaling Pathway in Juvenile Dermatomyositis.
Qi ZhengZhaoling WangYejun TanKun ZhuMei-Ping LuPublished in: Rheumatology and therapy (2024)
IL-6/JAK/STAT3 signaling pathway was abnormally activated in patients with JDM. IL-6 may be involved in the pathogenesis of muscle damage by triggering the development of calcium overload and production of ROS. Blockade of the IL-6/JAK/STAT3 pathway can be a potential treatment option for JDM, especially MDA5-positive patients and those who are negative for MSA.
Keyphrases
- signaling pathway
- end stage renal disease
- pi k akt
- chronic kidney disease
- ejection fraction
- newly diagnosed
- epithelial mesenchymal transition
- oxidative stress
- skeletal muscle
- cell death
- prognostic factors
- peritoneal dialysis
- interstitial lung disease
- risk assessment
- systemic sclerosis
- human health
- climate change
- endoplasmic reticulum stress
- combination therapy
- cell cycle arrest