Implications of LAG3 and CTLA4 immune checkpoints beyond PD-1/PD-L1 as a potential target in determining the prognosis of uveal melanoma patients.
Seema KashyapMithalesh Kumar SinghNikhil KumarJayanti JhaNeiwete LomiRachna MeelSameer BakhshiSeema SenLata SinghPublished in: The British journal of ophthalmology (2023)
Our findings suggest that higher levels of LAG3 in UM with histopathologically high-risk parameters predict high metastatic potential and that it could be used as a targeted immunotherapy alone or in combination with PD-1/PD-L1 blockade agents.