Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma-Derived Cells.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These results can help us understand targeted therapies with selective anticancer drugs in recurrent CNS lymphoma-acquired resistance against methotrexate.

Keyphrases

diffuse large b cell lymphoma
induced apoptosis
high dose
blood brain barrier
signaling pathway
cell cycle arrest
oxidative stress
pi k akt
weight gain
endoplasmic reticulum stress
low dose
cell proliferation
body mass index
wild type
physical activity