Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis.
Joshua J ManQing LuM Elizabeth MossBrigett CarvajalWendy BaurAmanda E GarzaRoy FreemanMarina AnastasiouNjabulo NgwenyamaGail K AdlerPilar AlcaideIris Z JaffePublished in: Arteriosclerosis, thrombosis, and vascular biology (2021)
These data identify PSGL1 as a My-MR target gene that drives leukocyte trafficking to enhance atherosclerotic plaque inflammation. These novel and sexually dimorphic findings provide insight into increased ischemia risk with MR activation, cardiovascular protection in women, and the role of MR in atherosclerosis and tissue inflammation.
Keyphrases
- contrast enhanced
- oxidative stress
- dendritic cells
- magnetic resonance
- cardiovascular disease
- polycystic ovary syndrome
- peripheral blood
- magnetic resonance imaging
- bone marrow
- coronary artery disease
- electronic health record
- copy number
- genome wide
- acute myeloid leukemia
- endothelial cells
- gene expression
- dna methylation
- pregnant women
- immune response
- skeletal muscle
- artificial intelligence
- deep learning
- breast cancer risk
- genome wide identification