Prior exposure to pathogens augments host heterogeneity in susceptibility and has key epidemiological consequences.

Individuals in a population can be highly variable in terms of whether or not they get sick during a pathogen outbreak. This individual variability in susceptibility has important consequences for how widely a disease can spread in a population. Therefore, it is key to understand what drives such variability in susceptibility among individuals. One possibility is that variable levels of standing immunity in a population, whether from vaccination or previous infection, lead to variability in susceptibility among individuals. We tested whether acquired immunity creates more variability in susceptibility among individuals in a host population, using a songbird disease system as a model. We found that birds that had acquired immunity to a bacterial pathogen were far more variable in their susceptibility. We also show that this population-level variability in itself can strongly suppress disease outbreaks.