Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators.
Euy Sung MoonFilipe ElvasGwendolyn VliegenStef De LombaerdeChristel VangestelSven De BruyckerAn BrackeElisabeth EppardLukas GreifensteinBenedikt KlasenVasko KramerSteven StaelensIngrid De MeesterPieter Van der VekenFrank RoeschPublished in: EJNMMI radiopharmacy and chemistry (2020)
In this work, novel PET radiotracers targeting fibroblast activation protein were synthesized and biochemically investigated. Critical substructures of the novel compounds are a squaramide linker unit derived from the basic motif of squaric acid, DOTA and DATA5m bifunctional chelators and a FAP-targeting moiety. In conclusion, these new FAP-ligands appear promising, both for further research and development as well as for first human application.