Downregulation of PIK3CB Involved in Alzheimer's Disease via Apoptosis, Axon Guidance, and FoxO Signaling Pathway.

Zhike ZhouJun BaiShanshan ZhongRongwei ZhangKexin KangXiaoqian ZhangYing XuChuansheng Zhao Mei Zhao

Published in: Oxidative medicine and cellular longevity (2022)

These findings highlight downregulated PIK3CB as a potential causative factor of AD, possibly mediated via apoptosis, axon guidance, and FoxO signaling pathway.

Keyphrases

signaling pathway
pi k akt
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
cell proliferation
induced apoptosis
epithelial mesenchymal transition
cell death
cognitive decline
transcription factor
optic nerve
human health
mild cognitive impairment