Population pharmacokinetics of levetiracetam in neonates with seizures.
V Lima-RogelE J López-LópezSusanna Edith Medellín-GaribayL M Gómez-RuizC Romero-MéndezR C Milán-SegoviaSilvia Romano-MorenoPublished in: Journal of clinical pharmacy and therapeutics (2017)
Based on the PK of LEV in neonates and the influence of the final PK model, a priori dosing guidelines are proposed considering CRCL, BW and LEV plasma concentrations between 6 and 20 mg/L for NS treatment.