CCND2 Modified mRNA Activates Cell Cycle of Cardiomyocytes in Hearts With Myocardial Infarction in Mice and Pigs.

Jiacheng SunLu WangRachel C MatthewsGregory P Walcott Yu-An LuYuhua WeiYang Zhou Lior Zangi Jianyi Jay Zhang

Published in: Circulation research (2023)

Intramyocardial injections of the CCND2-cardiomyocyte SMRTs promoted cardiomyocyte proliferation, reduced infarct size, and improved cardiac performance in small and large mammalian hearts with MI.

Keyphrases

cell cycle
high glucose
left ventricular
cell proliferation
angiotensin ii
acute myocardial infarction
heart failure
signaling pathway
high fat diet induced
endothelial cells
platelet rich plasma
ultrasound guided
metabolic syndrome
wild type
acute coronary syndrome