Three novel mixed ligand M(II) complexes, namely [CoL1L2Cl2] (1), [CuL1L2Cl2] (2), and [ZnL1L2Cl2] (3), were synthesized using 1,4-naphthoquinone, L-histidine, and 1,10-phenanthroline as ligands. The ligand framework and the corresponding structural changes on complexation were ascertained based on the results of elemental analysis, conductivity measurements, magnetic behavior, FT-IR, UV-visible, 1H NMR, 13C NMR, ESR spectral studies, and ESI mass spectrometry. The biological action of the ligand (L) and complexes 1-3 such as DNA binding and cleaving ability were studied. Results suggest that the ligand and the complexes could interact with calf thymus-DNA (CT-DNA) via intercalation mode. Additionally, complex 2 displayed potential antioxidant activity in in vitro studies. Docking simulation was performed to position the ligand and the complexes into the active site of BDNA (IBNA) to determine the probable binding mode.
Keyphrases
- dna binding
- transcription factor
- mass spectrometry
- magnetic resonance
- high resolution
- amino acid
- computed tomography
- case control
- ms ms
- solid state
- positron emission tomography
- molecular docking
- optical coherence tomography
- climate change
- image quality
- molecular dynamics
- estrogen receptor
- capillary electrophoresis
- protein protein
- small molecule
- tissue engineering