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Maintaining transcriptional homeostasis during cell cycle.

Lucía Ramos-AlonsoPierre Chymkowitch
Published in: Transcription (2023)
The preservation of gene expression patterns that define cellular identity throughout the cell division cycle is essential to perpetuate cellular lineages. However, the progression of cells through different phases of the cell cycle severely disrupts chromatin accessibility, epigenetic marks, and the recruitment of transcriptional regulators. Notably, chromatin is transiently disassembled during S-phase and undergoes drastic condensation during mitosis, which is a significant challenge to the preservation of gene expression patterns between cell generations. This article delves into the specific gene expression and chromatin regulatory mechanisms that facilitate the preservation of transcriptional identity during replication and mitosis. Furthermore, we emphasize our recent findings revealing the unconventional role of yeast centromeres and mitotic chromosomes in maintaining transcriptional fidelity beyond mitosis.
Keyphrases
  • gene expression
  • cell cycle
  • cell proliferation
  • dna methylation
  • transcription factor
  • single cell
  • cell therapy
  • induced apoptosis
  • genome wide
  • stem cells
  • signaling pathway
  • oxidative stress