Pregabalin for Recurrent Seizures in Critical Illness: A Promising Adjunctive Therapy, Especially for cyclic Seizures.
Katharina M BuslMichael W K FongZachary NewcomerMitesh PatelScott A CohenRakesh JadavChristine N SmithSotiris MitropanopoulosMaria BruzzoneMaria HellaStephan EisenschenkChristopher P RobinsonWilliam H RothPouya Alexander AmeliMarc-Alain BabiMichael A PizziEmily J GilmoreLawrence J HirschCarolina B MacielPublished in: Neurocritical care (2022)
PGB was associated with a relative reduction in seizure burden in neurocritically ill patients with recurrent seizures, especially those with cyclic seizures, and may be considered in the therapeutic arsenal for refractory seizures. Whether this effect is mediated via modulation of spreading depolarization requires further study.