FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in human dermal microvascular endothelial cells.
Celestina MazzottaGrace MardenG Alessandra FarinaAndreea M BujorMarcin A TrojanowskiMaria TrojanowskaPublished in: Microcirculation (New York, N.Y. : 1994) (2020)
Inhibition of cathepsin B was effective in reversing the reduction of friend leukemia integration 1 and erythroblast transformation-specific protein levels after treatment with interferon α or scleroderma sera, suggesting that targeting cathepsin B may have a beneficial effect in SSc vascular disease.