Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: implications for catheter ablation.
Michel HaïssaguerreGhassen ChnitiMélèze HociniFrederic SacherF Daniel RamirezHubert CochetLaura BearRomain TixierJosselin DuchateauRichard D WaltonElodie SurgetTsukasa KamakuraHugo MarchandNicolas DervalPierre BordacharSylvain PlouxTakamitsu TakagiThomas PambrunPierre JaisLouis LabrousseMark StrikHiroshi AshikagaHugh CalkinsEd VigmondKoonlawee NademaneeOlivier BernusRemi DuboisPublished in: European heart journal (2022)
The onset of human VF is mostly associated with activities from the Purkinje network and structural substrate, before spreading throughout the ventricles to establish sustained VF. Targeted ablation reduces or eliminates VF recurrence.