Sequencing Cell-free Fetal DNA in Pregnant Women With GCK-MODY.

Soo Heon Kwak Camille E PoweSe Song JangMichael J CallahanSarah N BernsteinSeung Mi LeeSunyoung KangKyong Soo ParkHak C JangJose C FlorezJong-Il KimJong Hee Chae

Published in: The Journal of clinical endocrinology and metabolism (2021)

We have successfully implemented a noninvasive method to predict fetal GCK genotype using cell-free DNA in 3 pregnant women carrying an inactivating GCK variant. This method could guide tailoring of hyperglycemia treatment in pregnancies of women with GCK monogenic diabetes.

Keyphrases

cell free
pregnant women
circulating tumor
pregnancy outcomes
type diabetes
cardiovascular disease
preterm birth
single cell
single molecule
gestational age
circulating tumor cells
combination therapy
weight loss
nucleic acid