Exposure to maternal obesity alters gene expression in the preimplantation ovine conceptus.

Sarah R McCoskiMcCauley T VailesConnor E OwensRebecca R CockrumAlan D Ealy

Published in: BMC genomics (2018)

Findings reveal that the preimplantation ovine conceptus genome responds to maternal obesity in a sex-dependent manner. The sexual dimorphism in response to the maternal environment coupled with changes in placental gene expression may explain aberrations in phenotype observed in offspring derived from obese females.

Keyphrases

gene expression
weight loss
birth weight
metabolic syndrome
weight gain
insulin resistance
type diabetes
dna methylation
pregnancy outcomes
genome wide
high fat diet induced
adipose tissue
high fat diet
bariatric surgery
mental health
body mass index
copy number
single cell