Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity.

Marc PfefferléIrina L DubachRaphael M BuzziElena DürstNadja Schulthess-LutzLivio BaselgiaKerstin HansenLarissa ImhofSandra KoernigDidier Le RoyThierry RogerRok HumarDominik J SchaerFlorence Vallelian

Published in: Journal for immunotherapy of cancer (2023)

Our study offers a targeted approach to uncouple CD40-augmented antitumor immunity in peripheral tissues from harmful inflammatoxicity in the liver.

Keyphrases

induced apoptosis
gene expression
oxidative stress
cell cycle arrest
high glucose
diabetic rats
cancer therapy
signaling pathway
drug induced
cell proliferation
virtual reality
pi k akt