Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction.

Chanichon Chomchoei James Michael Brimson Sirikalaya Brimson

Published in: Expert opinion on therapeutic targets (2023)

Fluoxetine may have the potential for acute leukemia treatment. Co-treatment with a σ1-R antagonist increases fluoxetine-induced apoptosis, possibly targeting AKT phosphorylation and autophagy activation.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
signaling pathway
oxidative stress
cell death
cell proliferation
bone marrow
risk assessment
smoking cessation
protein kinase
drug discovery