Login / Signup

Polyurethane Nanoparticle-Loaded Fenofibrate Exerts Inhibitory Effects on Nonalcoholic Fatty Liver Disease in Mice.

Yi-Ni CaoAsiya BaiyisaitiChui-Wei WongShan-Hui HsuRong Qi
Published in: Molecular pharmaceutics (2018)
Polyurethane (PU) nanoparticles are potential drug carriers. We aimed to study the in vitro and in vivo efficacy of biodegradable PU nanoparticles loaded with fenofibrate (FNB-PU) on nonalcoholic fatty liver disease (NAFLD). FNB-PU was prepared by a green process, and its preventive effects on NAFLD were investigated on HepG2 cells and mice. FNB-PU showed sustained in vitro FNB release profile. Compared to FNB crude drug, FNB-PU significantly decreased triglyceride content in HepG2 cells incubated with oleic acid and in livers of mice with NAFLD induced by a methionine choline deficient diet, and increased plasma FNB concentration of the mice. FNB-PU increased absorption of FNB and therefore enhanced the inhibitory effects of FNB on NAFLD.
Keyphrases
  • drug delivery
  • high fat diet induced
  • emergency department
  • physical activity
  • type diabetes
  • adipose tissue
  • insulin resistance
  • climate change
  • amino acid
  • atomic force microscopy