Ditocopheryl Sulfides and Disulfides: Synthesis and Antioxidant Profile.
Caterina ViglianisiKristian VasaDamiano TaniniAntonella CapperucciRiccardo AmoratiLuca ValgimigliAndrea BaschieriStefano MenichettiPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)
Symmetrical ditocopheryl disulfides (Toc)2 S2 and symmetrical and unsymmetrical ditocopheryl sulfides (Toc)2 S were simply prepared under remarkably mild conditions with complete control of the regiochemistry by using δ-, γ-, and β-tocopheryl-N-thiophthalimides (Toc-NSPht) as common starting materials. The roles of sulfur atom(s), H-bond and aryl ring substitution pattern on the antioxidant profile of these new compounds, which were assembled by linking together two tocopheryl units, are also discussed.