Near-Infrared Dye-Labeled Anti-Prostate Stem Cell Antigen Minibody Enables Real-Time Fluorescence Imaging and Targeted Surgery in Translational Mouse Models.
Mo ZhangNaoko KobayashiKirstin A ZettlitzEvelyn A KonoJoyce M YamashiroWen-Ting K TsaiZiyue K JiangChau P TranChung WangJohnny GuanAnna M WuRobert E ReiterPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Real-time fluorescence image-guided surgery with A11 Mb-IRDye800CW enabled detection of lymph node metastases and positive surgical margins, facilitated more complete tumor removal, and improved survival, compared with white light surgery. These results may be translatable into clinical practice to improve surgical and patient outcomes.
Keyphrases
- minimally invasive
- coronary artery bypass
- lymph node
- fluorescence imaging
- stem cells
- clinical practice
- surgical site infection
- prostate cancer
- mouse model
- photodynamic therapy
- bone marrow
- percutaneous coronary intervention
- squamous cell carcinoma
- acute coronary syndrome
- drug delivery
- radiation therapy
- benign prostatic hyperplasia