Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer.
Caroline BessonAmy MooreWenting WuClaire M VajdicSilvia de SanjoseNicola J CampKarin E SmedbyTait D ShanafeltLindsay M MortonJerry D BrewerLydia ZablotskaEric A EngelsJames R CerhanSusan L SlagerJiali HanSonja I Berndtnull nullPublished in: International journal of epidemiology (2021)
These findings highlight the role of pleiotropy regarding the pathogenesis of CLL and NMSC and shows that a single pleiotropic locus, 6p25.3, drives the observed association between genetic susceptibility to SCC and increased CLL risk. The study also provides evidence that genetic susceptibility for CLL increases BCC risk.