Opposite roles of Kindlin orthologs in cell survival and proliferation.

Irina ZhevlakovaLuyang XiongHuan LiuTejasvi DudikiAlieta CioceaEugene PodrezTatiana V Byzova

Published in: Cell proliferation (2022)

Kindlin ortologs and their interaction to cytoskeletal protein paxillin define the mechanisms of anchorage dependence. Our study identifies the key elements of the cell adhesion machinery in cell survival and tumour metastasis, proposing possible targets for tumour treatment.

Keyphrases

cell adhesion
signaling pathway
genome wide
protein protein
gene expression
combination therapy
dna methylation
small molecule