The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasome in Liver Disorders.
Xueqin LuHaitao HuangXiaodi FuChaoran ChenHuiyang LiuHonggang WangDong-Dong WuPublished in: International journal of molecular sciences (2022)
The endoplasmic reticulum (ER) is a key organelle responsible for the synthesis, modification, folding and assembly of proteins; calcium storage; and lipid synthesis. When ER homeostatic balance is disrupted by a variety of physiological and pathological factors-such as glucose deficiency, environmental toxins, Ca 2+ level changes, etc.-ER stress can be induced. Abnormal ER stress can be involved in many diseases. NOD-like receptor family pyrin domain-containing 3 (NLRP3), an intracellular receptor, can perceive internal and external stimuli. It binds to apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1 to assemble into a protein complex called the NLRP3 inflammasome. Evidence indicates that ER stress and the NLRP3 inflammasome participate in many pathological processes; however, the exact mechanism remains to be understood. In this review, we summarized the role of ER stress and the NLRP3 inflammasome in liver disorders and analyzed the mechanisms, to provide references for future related research.
Keyphrases
- nlrp inflammasome
- endoplasmic reticulum stress
- endoplasmic reticulum
- induced apoptosis
- cell death
- oxidative stress
- binding protein
- estrogen receptor
- breast cancer cells
- metabolic syndrome
- single molecule
- drug induced
- diabetic rats
- protein protein
- risk assessment
- adipose tissue
- replacement therapy
- endothelial cells
- human health
- density functional theory
- protein kinase