Microparticle Mediated Delivery of Apelin Improves Heart Function in Post Myocardial Infarction Mice.
Ling TangHui-Liang QiuBing XuYajuan SuVerah NyarigePengsheng LiHoujia ChenBrady KillhamJun LiaoHenderson AdamAaron YangAlexander YuMichelle JangMichael RubartAbdolkarim Talebi TaheriWuqiang ZhuPublished in: Circulation research (2024)
Poly(lactic-co-glycolic acid) microparticles prolonged the apelin release time in the mouse hearts. Epicardial delivery of the apelin-containing microparticle-embedded patch protects mice from both acute and chronic MI-induced cardiac dysfunction, inhibits cardiac fibrosis, and improves left ventricular remodeling.
Keyphrases
- left ventricular
- heart failure
- drug induced
- high fat diet induced
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- acute myocardial infarction
- mitral valve
- left atrial
- liver failure
- aortic stenosis
- high glucose
- respiratory failure
- oxidative stress
- atrial fibrillation
- coronary artery disease
- intensive care unit
- wild type
- type diabetes
- insulin resistance
- percutaneous coronary intervention