Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.
Nurgul SikhayevaAisha IskakovaNuria Saigi-MorguiElena ZholdybaevaChin-Bin EapErlan RamanculovPublished in: BMC medical genetics (2017)
We confirmed associations between polymorphisms within the SLC30A8, TSPAN8/LGR5, FABP2, and FTO genes and susceptibility to T2DM in a Kazakh cohort, and revealed significant associations with anthropometric and metabolic traits. In particular, FTO and FABP2 gene polymorphisms were significantly associated with susceptibility to MS and obesity in this cohort.
Keyphrases
- genome wide
- binding protein
- metabolic syndrome
- glycemic control
- mass spectrometry
- insulin resistance
- type diabetes
- weight loss
- multiple sclerosis
- body composition
- ms ms
- weight gain
- dna methylation
- single cell
- cardiovascular disease
- skeletal muscle
- gene expression
- adipose tissue
- cardiovascular risk factors
- genome wide identification
- bioinformatics analysis