Association between a 46-SNP Polygenic Risk Score and melanoma risk in Dutch patients with familial melanoma.

Thomas P PotjerTara W J van der GrintenInge M M LakemanSander H BollenMar Rodríguez-GirondoMark M IlesJennifer H BarrettLambertus A KiemeneyNelleke A GruisChristi J van AsperenNienke van der Stoep

Published in: Journal of medical genetics (2020)

Our work underlines the significance of a PRS in determining melanoma susceptibility and encourages further exploration of the diagnostic value of a PRS in genetically unexplained melanoma families.

Keyphrases

skin cancer
basal cell carcinoma
early onset
gene expression
breast cancer risk