Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; an exploratory study.

Eefje Martine van HelvoortJ Popov-CeleketicN EijkelkampK CoeleveldM A TryfonidouC D WijneC E HackF P J G LafeberS C Mastbergen

Published in: PloS one (2019)

This first study on the potential DMOAD activity upon prolonged repeated treatment with IL4-10 FP demonstrates that a species-specific variant has anti-inflammatory and chondroprotective effects in vitro and chondroprotective and analgesic effects in vivo. These data warrant further research on the DMOAD potential of the IL4-10 FP.

Keyphrases

anti inflammatory
machine learning
risk assessment
big data
combination therapy
smoking cessation