Tumor-derived GLI1 promotes remodeling of the immune tumor microenvironment in melanoma.

Alessandro GiammonaChiara De VellisEnrica CrivaroLuisa MarescaRoberta AmorielloFederica RicciGiulia AnichiniSilvia PietrobonoDavid R PeaseMartin E Fernandez-ZapicoClara BalleriniBarbara Stecca

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our findings highlight the relevance of tumor-derived GLI1 in promoting an immune-suppressive TME, which allows melanoma cells to evade the immune system, and pave the way for the design of new combination treatments targeting GLI1.

Keyphrases

cancer therapy
drug delivery
skin cancer