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HDL-cholesterol confers sensitivity of immunotherapy in nasopharyngeal carcinoma via remodeling tumor-associated macrophages towards the M1 phenotype.

Fan LuoJiaxin CaoHongyun ZhaoLusha LiuTing YangXue BaiWenjuan MaChaozhuo LinTing ZhouJianhua ZhanYan HuangYunpeng YangHongyun ZhaoLi Zhang
Published in: Journal for immunotherapy of cancer (2024)
Higher baseline HDL-C levels or an increase in HDL-C post-immunotherapy can enhance immunotherapeutic responses in patients with NPC by reprogramming M2-like macrophages towards the M1 phenotype. This suggests a potential role for prospectively exploring ApoA1 mimetics as adjuvant agents in combination with immunotherapy.
Keyphrases
  • early stage