SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

Ruona ShiXue ShiDajiang QinShibing TangMichiel VermeulenXiaofei Zhang

Published in: Cell & bioscience (2021)

In conclusion, our study demonstrated that SNX27 inhibits TNFα induced NF-κB signalling activation via facilitating OTULIN to localize to TNF receptor complex.

Keyphrases

signaling pathway
rheumatoid arthritis
lps induced
pi k akt
nuclear factor
inflammatory response
drug induced
immune response