L-lactate induces neurogenesis in the mouse ventricular-subventricular zone via the lactate receptor HCA1.

Marvin Lambertus Linda Thøring Øverberg Krister A AnderssonMalin S HjeldenAlena Hadzic Øyvind P Haugen Jon Storm-Mathisen Linda Hildegard BergersenSamuel GeiselerCecilie Morland

Published in: Acta physiologica (Oxford, England) (2020)

Our study demonstrates that neurogenesis in the two main neurogenic niches in the brain is regulated differently: Neurogenesis in both niches was induced by exercise, but only in the ventricular-subventricular zone was neurogenesis induced by lactate through HCA1 activation. This opens for a role of HCA1 in the physiological control of neurogenesis, and potentially in counteracting age-related cognitive decline.

Keyphrases

cerebral ischemia
cognitive decline
neural stem cells
heart failure
mild cognitive impairment
left ventricular
spinal cord injury
blood brain barrier
physical activity
transcription factor
resting state
atrial fibrillation
resistance training
body composition